Monday 21st October
8.30 Basement Lounge Light Breakfast
9.00 Studio 2: Welcome by Jarka Glassey from the ESBES Board and Ulrich Krühne from the local organizer
9.15 Studio 2: PL-1: Phenotypical heterogeneity in bioprocesses: better think positive!? – Anna Lena Heins and Alexander Grünberger
10.00 Basement Lounge Coffee Break
Studio 2 Digitalisation
Chair: Krist Gernaey
10.30 Comparison of vibrational spectroscopy methods for real-time monitoring of anaerobic fermentation. M. Mauricio Iglesias
10.45 Real-time cell population analysis in bioreactors using deep learning enabled in situ microscopy. J.-S. Guez
11.00 A “Legacy Zymer’s” Reflections on Industrial Digital Transformation at Novonesis. J. Price
11.15 Real-time state estimation in non-linear adsorption chromatography using Kalman filters. D. Espinoza
11.30 Industrial digital scale-up: Development of a versatile modelling platform M.O. Kaiser Albæk
Studio 3 Biocatalysis
Chair: Luuk van der Wielen
10.30 Planalyze: A Practical Framework for Bayesian Optimization – A Case Study Designing Experiments in Biocatalysis. M. Siska
10.45 Universal Microreactor for Flow Biocatalysis. M. Marques
11.00 Membrane modification strategies for high performance enzymatic membrane reactors. Z. Su
11.15 Optical Hydrogen Peroxide Sensor for at-line Monitoring. T. Mayr
11.30 Enzyme immobilisation technology at industrial scale: challenges and prospects. P. Andric
Studio 4 Biotechnology and metabolic engineering
Chair: John Kavanagh
10.30 Enhancing Xylose Utilization in Bioprocessing: Insights from XUT1 Gene Functional Characterization from Candida tropicalis. S. de Souza Queiroz
10.45 High-precision profiling of population dynamics and metabolites unravels joint biotransformation of natural products in cellulosic co-cultures. A. Palacio-Barrera
11.00 Proteome reduction as a strategy to improve the performance of cell factories. A. R. Lara
11.15 Demonstrating the capabilities of KIWI-Biolab’s robotic ecosystem by orchestration of model-mased DoEs and fast in-depth analytics for the development of recombinant protein processes. P. Neubauer
11.30Utilization of spent sulfite liquor as substrate and inducer for protein production in engineered Corynebacterium glutamicum strains. G. Seibold
12.00 Lounge First Floor: Lunch
Studio 2: Digitalisation
Chair: Ulrich Krühne
13.00 The BioProcessNexus: One step towards free and accessible techno economic bioprocess models. M. Medl
13.15 A Physics -Informed Neural Network (PINNs) Framework for Bioreactor Hybrid Modelling. M. Kumar Thirugnanasambandam
13.30 Uncertainty-aware real-time forecasting of pilot-scale bubble column aeration using ensemble hybrid model. P. Jul-Rasmussen
13.45 The more, the merrier? A quest for an efficient compartmentalization strategy for CFD-based analyses of bioreactors. H. Maldonado De Leon
14.00 Advanced simulation of large-scale bioreactors. J. Le Nepvou De Carfort
14.15 Creating a Digital Twin for a Pilot-Plant Disk Centrifuge in GFPuv Production, A. A. Malanca
Studio 3: Biocatalysis
Chair Bruno Bühler
13.00 Development of Enzymes from Extremophiles for the Degradation of Plastics and Potential Generatio of Useful Metabolites. J. Asenjo
13.15 Continuous synthesis of furfurylamine in a falling film microflow reactor with integrated product separation M. Božinović
13.30 Localisation of lipases inside pickering emulsions – Investigation through adsorption behaviour M. Seiler
13.45 Model-assisted Design and Optimization of a Biocatalytical Cofactor Regeneration Process in a Pressurized Packed-Bed Reactor. L. Arndt
14.00 Process intensification guided by techno-economic analysis for the bioconversion of rutin. Z. Kádár
14.15 Structural and biochemical characterization of vanillin aminotransferases for the biological valorization of lignin. I.Mendes Bonfim
Studio 4: Biotechnology and metabolic engineering
Chair: Peter Neubauer
13.00 Populations under stress: assessment of morphology and physiology heterogeneity in mono- and co-cultivation. S. Junne
13.15 Automated adaptive laboratory evolution of Clostridium kluyveri enables growth at high CO partial pressures. V. Burgmaier
13.30 Metabolic Engineering of new Streptomyces sp. from Extreme Environments for Novel Antibiotics, Anticancer and Antifungal Drugs. B. Andrews
13.45 Enhanced productivity of filamentous pellets investigated with new tools for elucidation of oxygen uptake and morphology. Z. Justyna Kozanecka
14.00 Selection and characterization of microbiomes under the same ecological stress. M. Catalão
14.15Use of bacterial co-culture to overcome the toxicity of lignocellulosic hydrolysates. S. I. Mussatto
14.30 Basement Lounge: Coffee Break
15.00 Poster Presentations at the different locations
16.30 Free Time
18.00 – 19.30 Pancake reception at Copenhagen Town Hall
Tuesday 22nd October
8.30 Basement Lounge: Light Breakfast
9.00 Studio 2: PL-2: Added value from reconstructed biomass fractions: Tackling lignin particle aggregation through hemicellulose- and laccase-assisted bioprocess. Kirsi S. Mikkone
10.00 Basement Lounge: Coffee Break
Studio 2: FBM Scaling, Gradients and Heterogenity
Chair: John Woodley
10.30-10.40 Welcome by Bjarke Bak Christensen
10.40-11.05 The start of green transition by the use of fermentation of large volume food and material proteins. P. Falholt
11.05-11.30 Gradients in fermentations conditions can impact process performance by leading to decreased yields in large-scale fermentation processes. G. Nadal-Rey
11.30 Optimizing seed train design: Enhancing productivity in biomanufacturing scale-up. L Munkler
Studio 3: Novel upstream and downstream process concepts
Chair: Carina L. Gargola
10.30 Photoautotrophic production of DHA and EPA enriched biomass by co-culturing golden brown and green microalgae. A.-L. Thurn
10.45 Manufacturing of recombinant disulphide-bonded peptides in Escherichia coli using CASPON™ technology. B. Striedner
11.00 Expansion of T-cells Using a Perfused Microfluidic Approach. O. Derevianko
11.15 Upcycling of PET-based plastic waste into biodegradable polyhydroxyalkanoates (PHA) using mixed microbial cultures. P. Concórdio-Reis
11.30 Bioprocess monitoring with miniaturized multi-parameter electrochemical sensors. A. Hasanzadeh
Studio 4: Circular bioeconomy and processing
Chair: Solange L. Mussatto
10.30 All-in-one: Direct conversion of cellulose to erythro-isocitric acid by a non-engineered strain of Talaromyces verruculosus. I. Schlembach
10.45 PEM Electrocatalysis in a Stirred-Tank Bioreactor Enables Growth of Clostridium ragsdalei with CO2 and Electrons. I. Schwarz
11.00 Bringing food waste back to the food value chain using SustainMAX® technology. P. Madhusudan Bapat
11.15 Integrating process modeling and impacts into an automated sustainability assessment toolbox of bio-based products. S. Sukumara
11.30 Towards Sustainable Food Security: Exploiting Synthetic Microbial Communities for Protein Production from Dairy Industry side streams. B. Delmoitié
12.00 Lounge First Floor: Lunch break
Studio 2: FBM Innovation for Biomanufactoring
Chair: Andreas Worberg
13.00-13.20 Planetary Health at the BioInnovation Institute Maria Henriques De Jesus, BII
13.20-13.40 Next-generation food innovation
Johan Agrell, Alfa Laval
13.40-14.00 Food Innovation with Filamentous Fungi
Leonie Johanna Jahn, DTU
14.00-14.20 Valorization of end-of-life waste streams to high-value products. P. Reitzer
14.20-14.40 Breaking the cost barrier – biomanufacturing with FAST continuous extractive fermentation
Eric van der Meer, DAB
Studio 3: Digitalisation
Chair: TBA
13.00 Deep Hybrid Modelling of a Supercritical CO2 Extraction Process. R. Agharafeie
13.15 Bioprocessing 5.0: From Knowledge Graphs to Cognitive Digital Threads. M. Nicolas Cruz Bournazou
13.30 Applying a Modified DevOps Workflow to Address Challenges in Developing Digitalisation Tools for Chemical and Biochemical Manufacturing. M. Stevnsborg
13.45 A Novel Machine-Learning-Based Scaling Tool for Bioreactors Using CFD Simulation Data. C. Witz
14.00 Merging metabolic networks with deep neural networks under the SBML standard Abstract. J. Pinto
14.15 Process Modeling accelerates bioprocess development and enables digital biomanufacturing. M. Krippl
Studio 4: Biopharmaceutical Process
Chair: Raquel Aires-Barros
13.00 Rational bioprocess development and optimalisation for cultured Red Blood Cells (cRBCs). L. van Der Wielen
13.15 Techno-economic Optimization under Uncertainty for
Pharmaceutical Processes: Ibuprofen. T. Asrav
13.30 Enhancement of mRNA quality for improved vaccine development. A. Rita Santos
13.45 Towards cfDNA extraction from plasma for liquid biopsy applications – partitioning behavior of short DNA. R. Meutelet
14.00 Flocculants for reduction of (high-risk) host cell proteins during primary recovery of monoclonal antibody production processes. A.-C. Frank
14.15 Biomanufacturing Decisions with Data and Models. P. Ramin
14.30: Basement Lounge: Coffee Break
15.00 Poster Session
16.30 Free Time
18.30-22.30 Gala Dinner at National Museum
23rd of October
8.30: Basement Lounge: Light Breakfast
9.00 Studio 2: PL-3: Intensification of biocatalytic processes towards industrial volumetric productivities – Selin Kara
10.00 Basement Lounge: Coffee Break
Studio 2: Biopharmaceutical process
Chair: Tiffany Rau
10.30 Automatic kLa Determination in Stirred Tank Reactors by Model-Based Design of Experiments. A. H. Valdeira Caetano
10.45 A Hierarchical Approach for Evaluation of Lost Throughput in API Manufacturing. T. Overgaard
11.00 CFD-guided scale-down for end-in-mind bioreactor development: from 2000 L to 2 L. M. Segami
11.15 Vibrio natriegens as a new host for plasmid DNA production. D. Miguel Prazeres
11.30 Purification and characterization of recombinant neuraminidase for non-seasonal vaccine against Influenza virus. F. De Mathia
11.45 Efficient Media and Buffer Formulation Development with Mixture Experiments using Space Filling Designs and Machine Learning. T. Rau
Studio 3: Industrial water and wastewater technology
Chair: TBA
10.30 Immobilization of laccase from Lentinus sajor-caju on chitosan-clay beads and applications on sulfamethoxazole degradation. H. Sá
10.45 Sustainable power generation from salinity gradients via Pressure Retarded Osmosis (PRO): Membrane modification for improved performance. M. Malankowska
11.00 Modelling partial nitration/anammox processes in a full-scale aerobic granular sludge reactor treating reject water. X. Flores-Alsina
11.15 Unveiling the water-energy nexus: Wastewater reuse for district heating applications. F. Sousa Braga
11.30 Bio-release of toxic elements from mining waste. A. Pawlowska
11.45 A preliminary study on the growth of mushroom mycelia via submerged fermentation utilizing a cheap agro-industrial waste. E. Akpari
Studio 4: Bioenergy
Chair: Tony Kiss
10.30 Unveiling biochar’s role in Anaerobic Digestion: myths and facts for enhanced biogas production and sulfate inhibition mitigation. G. Vayena
10.45 Conversion off Oxalic-Acid Impregnated Biomass into Glucose and Bioethanol with the Assistance of Microwave-Irradiation. R. Ceaser
11.00 Computational Simulation of the Pressure-Retarded Osmosis: a Multi-Scale Multi-Physics Membrane-Based Process. M. Mohammadi Amin
11.15 Modeling and Simulation of Biological Water-Gas Shift Reaction in Trickle Bed Reactor and Comparison With CSTR. S. Dutta
11.30 Effect of feeding regime and pH on thermophilic acidogenic fermentations from food waste. L. Vulart
11.45 Maximizing bioenergy production from agro-industrial and municipal wastes in Jalisco: analysis of feedstock effects on the biogas yield of anaerobic co-digestions. M. S. G. Hernández
12.00 Lounge First Floor: Lunch Break
Studio 2: Biopharmaceutical process
Chair: Arne Staby
13.00 Microbial Process Transfer at Boehringer Ingelheim. E.M. Wlaschitz
13.15 Chemotools: a modern open-source Python software for endto-end PAT applications. P. Cabaneros
13.30 Novel dual-stage cross-flow filtration-based setup for virus-like particle capture. A. Dietrich
13.45 Autonomous operation and quality monitoring of a continuous antibody downstream process. M. Isaksson
14.00 Hybrid model for mesenchymal stem cell cultivation processes
incorporating seeding heterogeneity. K. Hirono
14.15 Novel filtration technology allows for
simpler and more efficient
separation/recovery of api from biomass and downstream processing. A. Poulsen
Studio 3: Bioprocess for food engineering/precision fermentation
Chair: Marcel Ottens
13.00 Bottlenecks and Opportunities in Cultivated Meat Production. J. Pereira
13.15 Production of Proteins by Precision Fermentation. P. Falholt
13.30 Establishing a High-Throughput Co-Culture Platform to Systematically Screen Diverse Strptomyces Species for new Natural Products. D. Miriam Schütterle
13.45 Modelling of Transport Phenomena and process induced quality Changes During Baking of Soft-Baked Goods. A. H. Feyissa
14.00 The impact of common fermentation medium salts on local holdup in bubble column bioreactors. C. Haringa
14.15 Bubble Column measurements and modelling. J. Kavanagh
Studio 4: Education/New (bio)materials for process engineering
Chair: TBA
13.00 Project Based Teaching of Biochemical Engineering. J. Kavanagh
13.15 Bioprocess Design Education at TU Delft. T. Kiss
13.30 ChatGMP: a Digital Audit Tool for Good Manufacturing Practices. F. Caccavale
13.45 Biosynthesis of Polyhydroxyalkanoates from Lignin Monomers by Halophiles: High-Throughput Screening and Understanding Limitations. V. Andhalkar
14.00 Fermentative production and purification of L-(+)-lactic acid: assessing the potential of tree and shrub species growing on marginal land. L. Schroedter
14.15 Novel applications in a redesigned 3D-printed micro bubble column reactor. G. Schultz
14.30 Basement Lounge: Coffee Break
15.00 Studio 2: Award Ceremony (poster and oral presentation)
15.30 Closing Remarks
16.15 End of Conference