Monday 21st October

Studio 2 Digitalisation

Chair: Krist Gernaey

10.30 Comparison of vibrational spectroscopy methods for real-time monitoring of anaerobic fermentation. M. Mauricio Iglesias Universidade De Santiago De Compostela

10.45 Real-time cell population analysis in bioreactors using deep learning enabled in situ microscopy. J.-S. Guez Université Clermont Auvergne / Institut Pascal

11.00 A “Legacy Zymer’s” Reflections on Industrial Digital Transformation at Novonesis. J. Price Novonesis A/S

11.15 Real-time state estimation in non-linear adsorption chromatography using Kalman filters. D. Espinoza Lund University

11.30 Industrial digital scale-up: Development of a versatile modelling platform M.O. Kaiser Albæk Novonesis A/S

Studio 4 Biotechnology and metabolic engineering

Chair: John Kavanagh

10.30 Enhancing Xylose Utilization in Bioprocessing: Insights from XUT1 Gene Functional Characterization from Candida tropicalis. S. de Souza Queiroz Technical University Of Denmark

10.45 High-precision profiling of population dynamics and metabolites unravels joint biotransformation of natural products in cellulosic co-cultures. A. Palacio-Barrera Leibniz HKI

11.00 Proteome reduction as a strategy to improve the performance of cell factories. A. R. Lara Aarhus University

11.15 Demonstrating the capabilities of KIWI-Biolab’s robotic ecosystem by orchestration of model-mased DoEs and fast in-depth analytics for the development of recombinant protein processes. M. Nicolas Cruz Bournazou Bio-PAT e.V.

11.30 Utilization of spent sulfite liquor as substrate and inducer for protein production in engineered Corynebacterium glutamicum strains. G. Seibold Technical University Of Denmark

Studio 2: Digitalisation

Chair: Ulrich Krühne

13.00 The BioProcessNexus: One step towards free and accessible techno economic bioprocess models. M. Medl BOKU Vienna

13.15 A Physics -Informed Neural Network (PINNs) Framework for Bioreactor Hybrid Modelling. M. Kumar Thirugnanasambandam Universidade Nova de Lisboa

13.30 Uncertainty-aware real-time forecasting of pilot-scale bubble column aeration using ensemble hybrid model. P. Jul-Rasmussen Technical University of Denmark

13.45 The more, the merrier? A quest for an efficient compartmentalization strategy for CFD-based analyses of bioreactors. H. Maldonado De Leon Delft University Of Technology

14.00 Advanced simulation of large-scale bioreactors. J. Le Nepvou De Carfort Technical University of Denmark

14.15 Creating a Digital Twin for a Pilot-Plant Disk Centrifuge in GFPuv Production, A. A. Malanca Technical University of Denmark

Studio 3: Biocatalysis

Chair Bruno Bühler

13.00 Development of Enzymes from Extremophiles for the Degradation of Plastics and Potential Generatio of Useful Metabolites. J. Asenjo Centre for Biotechnology and Bioengineering, University of Chile

13.15 Continuous synthesis of furfurylamine in a falling film microflow reactor with integrated product separation M. Božinović University Of Ljubljana

13.30 Localisation of lipases inside pickering emulsions – Investigation through adsorption behaviour M. Seiler HTW Berlin

13.45 Model-assisted Design and Optimization of a Biocatalytical Cofactor Regeneration Process in a Pressurized Packed-Bed Reactor. L. Arndt Hamburg University of Technology

14.00 Process intensification guided by techno-economic analysis for the bioconversion of rutin. P. de Brabander Bio Base Europe Pilot Plant

14.15 Structural and biochemical characterization of vanillin aminotransferases for the biological valorization of lignin. I.Mendes Bonfim Lund University

Studio 4: Biotechnology and metabolic engineering

Chair: Stefan Junne

13.00 Populations under stress: assessment of morphology and physiology heterogeneity in mono- and co-cultivation. S. Junne Aalborg University

13.15 Automated adaptive laboratory evolution of Clostridium kluyveri enables growth at high CO partial pressures. V. Burgmaier Technical University of Munich

13.30 Metabolic Engineering of new Streptomyces sp. from Extreme Environments for Novel Antibiotics, Anticancer and Antifungal Drugs. J. Asenjo Centre for Biotechnology and Bioengineering, University of Chile

13.45 Enhanced productivity of filamentous pellets investigated with new tools for elucidation of oxygen uptake and morphology. Z. J. Kozanecka TU Braunschweig

14.00 Selection and characterization of microbiomes under the same ecological stress. M. Catalão FCT Nova Lisbon

14.15 Use of bacterial co-culture to overcome the toxicity of lignocellulosic hydrolysates. S. I. Mussatto Technical University of Denmark

15.00 Poster Session (all posters are shown)

15.00 Studio 3: ESBES educational section meeting, J. Glassey Newcastle University

1. Education section aims and objectives
2. Membership of section
3. Activities
   1. ECCE/ECAB Lisbon 2025, other opportunities?
   2. Summer schools?
   3. Position papers?
4. Collaborations with partners

15.00 Poster Session (all posters are shown)

Studio 2: FBM Scaling, Gradients and Heterogenity

Chair: John Woodley

10.30-10.40 Welcome by Bjarke Bak Christensen Technical University of Denmark

10.40-11.05 The start of green transition by the use of fermentation of large volume food and material proteins. P. Falholt 21 Bio

11.05-11.30 Gradients in fermentations conditions can impact process performance by leading to decreased yields in large-scale fermentation processes. G. Nadal-Rey Novonesis A/S

11.30 Optimizing seed train design: Enhancing productivity in biomanufacturing scale-up. L. Munkler Technical University of Denmark

Studio 3: Novel upstream and downstream process concepts

Chair: Carina L. Gargalo

10.30 Photoautotrophic production of DHA and EPA enriched biomass by co-culturing golden brown and green microalgae. A.-L. Thurn Technical University Of Munich

10.45 Manufacturing of recombinant disulphide-bonded peptides in Escherichia coli using CASPON™ technology. G. Striedner BOKU University

11.00 Expansion of T-cells Using a Perfused Microfluidic Approach. O. Derevianko UCL

11.15 Upcycling of PET-based plastic waste into biodegradable polyhydroxyalkanoates (PHA) using mixed microbial cultures. P. Concórdio-Reis Nova School Of Science And Technology, Lisbon

11.30 Bioprocess monitoring with miniaturized multi-parameter electrochemical sensors. A. Hasanzadeh Technical University of Denmark

Studio 4: Circular bioeconomy and processing

Chair: Solange I. Mussatto

10.30 All-in-one: Direct conversion of cellulose to erythro-isocitric acid by a non-engineered strain of Talaromyces verruculosus. I. Schlembach Leibniz Institute

10.45 PEM Electrocatalysis in a Stirred-Tank Bioreactor Enables Growth of Clostridium ragsdalei with CO₂ and Electrons. I. Schwarz Technical University Munich

11.00 Bringing food waste back to the food value chain using SustainMAX® technology. P. Madhusudan Bapat G2B Biosolutions

11.15 Integrating process modeling and impacts into an automated sustainability assessment toolbox of bio-based products. S. Sukumara Technical University of Denmark

11.30 Towards Sustainable Food Security: Exploiting Synthetic Microbial Communities for Protein Production from Dairy Industry side streams. B. Delmoitié Ghent University

Studio 2: FBM Innovation for Biomanufactoring

Chair: Andreas Worberg

13.00-13.20 Planetary Health at the BioInnovation Institute Maria Henriques De Jesus, BII

13.20-13.40 Next-generation food innovation
Johan Agrell, Alfa Laval

13.40-14.00 Food Innovation with Filamentous Fungi
Leonie Johanna Jahn, Technical University of Denmark

14.00-14.20 Valorization of end-of-life waste streams to high-value products. P. Reitzer University of Nottingham

14.20-14.40 Breaking the cost barrier – biomanufacturing with FAST continuous extractive fermentation
Eric van der Meer, DAB

Studio 3: Digitalisation

Chair: Mads Orla Kaiser-Albæk

13.00 Deep Hybrid Modelling of a Supercritical CO₂ Extraction Process. R. Agharafeie Universidade Nova De Lisboa

13.15 Bioprocessing 5.0: From Knowledge Graphs to Cognitive Digital Threads. M. Nicolas Cruz Bournazou Bio-PAT e.V.

13.30 Applying a Modified DevOps Workflow to Address Challenges in Developing Digitalisation Tools for Chemical and Biochemical Manufacturing. M. Stevnsborg Technical University of Denmark

13.45 A Novel Machine-Learning-Based Scaling Tool for Bioreactors Using CFD Simulation Data. C. Witz SimVantage Gmbh

14.00 Merging metabolic networks with deep neural networks under the SBML standard Abstract. J. Pinto Universidade Nova De Lisboa

14.15 Process Modeling accelerates bioprocess development and enables digital biomanufacturing. M. Krippl Novasign GmbH

Studio 4: Biopharmaceutical Process

Chair: Raquel Aires-Barros

13.00 Rational bioprocess development and optimalisation for cultured Red Blood Cells (cRBCs). L. van Der Wielen TU Delft & Bernal Institute, U Limerick

13.15 Techno-economic Optimization under Uncertainty for
Pharmaceutical Processes: Ibuprofen. T. Asrav Technical University of Denmark

13.30 Enhancement of mRNA quality for improved vaccine development. A. Rita Santos Institute For Bioengineering and Biosciences

13.45 Towards cfDNA extraction from plasma for liquid biopsy applications – partitioning behavior of short DNA. R. Meutelet Karlsruhe Institute of Technology

14.00 Flocculants for reduction of (high-risk) host cell proteins during primary recovery of monoclonal antibody production processes. A. C. Frank Boku University

14.15 Navigating Biomanufacturing Decisions with Data and Models. P. Ramin Technical University of Denmark

Studio 2: Biopharmaceutical process

Chair: Tiffany Rau

10.30 Automatic kLa Determination in Stirred Tank Reactors by Model-Based Design of Experiments. A. H. Valdeira Caetano Technical University of Denmark

10.45 A Hierarchical Approach for Evaluation of Lost Throughput in API Manufacturing. T. Overgaard Technical University of Denmark

11.00 CFD-guided scale-down for end-in-mind bioreactor development: from 2000 L to 2 L. M. Segami TU Delft

11.15 Vibrio natriegens as a new host for plasmid DNA production. D. Miguel Prazeres Instituto Superior Técnico

11.30 Purification and characterization of recombinant neuraminidase for non-seasonal vaccine against Influenza virus. F. De Mathia Boku University

11.45 Efficient Media and Buffer Formulation Development with Mixture Experiments using Space Filling Designs and Machine Learning. T. Rau Rau Consulting/ Bio Pharma Technical Consulting

Studio 3: Industrial water and wastewater technology

Chair: Elham Ramin

10.30 Immobilization of laccase from Lentinus sajor-caju on chitosan-clay beads and applications on sulfamethoxazole degradation. H. Sá University Of Minho

10.45 Sustainable power generation from salinity gradients via Pressure Retarded Osmosis (PRO): Membrane modification for improved performance. M. Malankowska Technical University of Denmark

11.00 Modelling partial nitration/anammox processes in a full-scale aerobic granular sludge reactor treating reject water. X. Flores-Alsina Technical University of Denmark

11.15 Unveiling the water-energy nexus: Wastewater reuse for district heating applications. F. Sousa Braga Technical University of Denmark

11.30 Bio-release of toxic elements from mining waste. A. Pawlowska Wroclaw University of Science and Technology

11.45 A preliminary study on the growth of mushroom mycelia via submerged fermentation utilizing a cheap agro-industrial waste. E. Akpari Aalto University

Studio 4: Bioenergy

Chair: Tony Kiss

10.30 Unveiling biochar’s role in Anaerobic Digestion: myths and facts for enhanced biogas production and sulfate inhibition mitigation. G. Vayena Technical University of Denmark

10.45 Conversion off Oxalic-Acid Impregnated Biomass into Glucose and Bioethanol with the Assistance of Microwave-Irradiation. R. Ceaser Rovira iVirgili

11.00 Computational Simulation of the Pressure-Retarded Osmosis: a Multi-Scale Multi-Physics Membrane-Based Process. M. Mohammadi Amin Technical University of Denmark

11.15 Modeling and Simulation of Biological Water-Gas Shift Reaction in Trickle Bed Reactor and Comparison With CSTR. S. Dutta Technical University of Denmark

11.30 Effect of feeding regime and pH on thermophilic acidogenic fermentations from food waste. L. Vulart Ghent University

11.45 Maximizing bioenergy production from agro-industrial and municipal wastes in Jalisco: analysis of feedstock effects on the biogas yield of anaerobic co-digestions. M. S. G. Hernández

Studio 2: Biopharmaceutical process

Chair: Arne Staby

13.00 Microbial Process Transfer at Boehringer Ingelheim. E.M. Wlaschitz Boehringer Ingelheim

13.15 Chemotools: a modern open-source Python software for endto-end PAT applications. P. Cabaneros Novo Nordisk

13.30 Novel dual-stage cross-flow filtration-based setup for virus-like particle capture. A. Dietrich Karlsruhe Institute of Technology

13.45 Autonomous operation and quality monitoring of a continuous antibody downstream process. J. K. Lorek Lund University

14.00 Hybrid model for mesenchymal stem cell cultivation processes
incorporating seeding heterogeneity. K. Hirono The University of Tokyo

14.15 Novel filtration technology allows for
simpler and more efficient
separation/recovery of api from biomass and downstream processing. J. Robin SANI Membranes A/S

Studio 3: Bioprocess for food engineering/precision fermentation

Chair: Marcel Ottens

13.00 Bottlenecks and Opportunities in Cultivated Meat Production. J. Pereira TU Delft

13.15 Biosynthesis of Polyhydroxyalkanoates from Lignin Monomers by   Halophiles: High-Throughput Screening and Understanding Limitations. V. Andhalkar Universitat Rovira i Virgili

13.30 Establishing a High-Throughput Co-Culture Platform to Systematically Screen Diverse Strptomyces Species for new Natural Products. D. Miriam Schütterle Leibniz Institute

13.45 Modelling of Transport Phenomena and process induced quality Changes During Baking of Soft-Baked Goods. A. H. Feyissa Technical University of Denmark

14.00 The impact of common fermentation medium salts on local holdup in bubble column bioreactors. C. Haringa TU Delft

14.15 Bubble Column measurements and modelling. J. Kavanagh University of Sydney

Studio 4: Education/New (bio)materials for process engineering

Chair: Krist Gernaey

13.00 Project Based Teaching of Biochemical Engineering. J. Kavanagh University of Sydney

13.15 Bioprocess Design Education at TU Delft. T. Kiss TU Delft

13.30 ChatGMP: a Digital Audit Tool for Good Manufacturing Practices. F. Caccavale Technical University of Denmark

13.45 Helix Lab Research and Education Center – Project work with bioindustry in Kalundborg A. Birck Helix Lab

14.00 Fermentative production and purification of L-(+)-lactic acid: assessing the potential of tree and shrub species growing on marginal land. L. Schroedter Leibniz Institut

14.15 Novel applications in a redesigned 3D-printed micro bubble column reactor. G. Schultz TU Braunschweig